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The strain is New Zealand White (NZW). Transgenic rabbit founder was produced by microinjection of green fluorescent protein (GFP) expression gene into the pronuclear nucleus of a fertilized rabbit egg. The GFP rabbits exhibit bright green fluorescence when exposed to blue light at the wavelength of 484 nm excitation maximum. The cell culture of ear explant tissue indicates the GFP expression over to passage 25-30 under fluorescent microscopy.
NZW founder (male) (GFP+/-) mates with several females (GFP-/-) to generate about 50% positive heterozygous GFP F1 with genotype (GFP+/-). We are currently developing homozygous GFP (GFP+/+) rabbits, and the homozygous line will be available at the end of 2012. The location of GFP transgene on the chromosome is under determination.
All heterozygous GFP F1 rabbits (GFP+/-) are genotyped before sell. Quality control makes sure GFP gene is transmitted in all cell type, the animals and derivative tissues/cells express GFP.
The new lines of GFP rabbits can be used for study many human related diseases, such as CVD, HIV, regenerative disease and cancer. The specific relevant or derived GFP rabbit cell types can be used for gene therapy in animal models. GFP transgenic rabbits can also be used for deriving embryonic stem cells (from the early embryos), induced pluripotent stem (iPS) cells, and further differentiation into many specific cell types. Those cells carry the GFP gene and can be traceable during the development and differentiation, as well as cell migration during the process, especially during the study of cell based therapy.
Product #: GFP_RAB
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GFP F1 lines are for research only, and under the Material Transfer Agreement (MTA) with Renova Life Inc (RLI). The price of order will be based on the quantity of animals ordered.
You can place your order by
phone (904-379-6507) or fax (301-576-5078).
You can also send your inquiries to us
following this link.
PRE-ORDER REQUEST IS REQUIRED.
Thank you for your business.
Special Shipping Notice: GFP F1 rabbits will be shipped from oversea. The process will strictly follow the regulations of USDA. Please allow 6-8 months for order delivery.
Disclaimer: For research use only. Not for clinical, drug, household or other uses. The above information is believed to be correct but does not purport to be all-inclusive and shall be used only as a guide. Renova Life Inc. shall have no liability for any direct, indirect, consequential or incidental damages arising out of the use, the results of use, the inability to use, the handling or contact with this product.
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