Products and Services | Neomycin Resistant Rabbits

Product Description:

The strain is New Zealand White (NZW). Transgenic rabbit founder was produced by microinjection of Neomycin (Neo) expression gene into the pronuclear nucleus of a fertilized rabbit egg. A Neo gene is commonly included in DNA plasmids used by molecular biologists to establish stable mammalian cell lines expressing cloned proteins in culture as a selectable marker. The Neo rabbits exhibit resistant function to geneticin (G418) in their tissues and cells.


NZW founder (male) (Neo+/-) mates with several females (Neo-/-) to generate about 50% positive heterozygous Neo F1 with genotype (Neo+/-). We are currently developing homozygous Neo (Neo+/+) rabbits, and the homozygous line will be available at the end of 2012. The location of Neo transgene on the chromosome is under determination.

 

All heterozygous Neo F1 rabbits (Neo+/-) are genotyped before sell. Quality control makes sure Neo gene is transmitted in all cell type, the animals and derivative tissues/cells express Neo.


The new lines of Neo rabbits can be used for basic studies in human related diseases, such as CVD, HIV, regenerative disease and cancer. Neo transgenic rabbits can also be used for deriving embryonic stem cells (from the early embryos), induced pluripotent stem (iPS) cells, and further differentiation into many specific cell types. The Neo resistant cell lines can be used for feeder cells of ES cells and iPS during the genetic manipulation of targeted cells. During the cell based therapy study, those Neo positive cells can be traceable for cell migration during the development and differentiation.



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Product #: NEO_RAB
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Neo F1 lines are for research only, and under the Material Transfer Agreement (MTA) with Renova Life Inc (RLI). The price of order will be based on the quantity of animals ordered.

You can place your order by phone (904-379-6507) or fax (301-576-5078).
You can also send your inquiries to us following this link.

PRE-ORDER REQUEST IS REQUIRED.
Thank you for your business.

Special Shipping Notice: Neo F1 rabbits will be shipped from oversea. The process will strictly follow the regulations of USDA. Please allow 6-8 months for order delivery.

Disclaimer: For research use only. Not for clinical, drug, household or other uses. The above information is believed to be correct but does not purport to be all-inclusive and shall be used only as a guide. Renova Life Inc. shall have no liability for any direct, indirect, consequential or incidental damages arising out of the use, the results of use, the inability to use, the handling or contact with this product.

 

Products and Services | Neomycin Resistant Rabbits